ABSTRACT
Objectives: To observe the preventive effects of combined nicorandil with trimetazidine strategy on contrast-induced nephrophathy in patients undergoing elective percutaneous coronary intervention (PCI). Methods: 521 patients with acute coronary syndrome undergoing elective PCI were randomly divided into 4 groups:control group (n=208), nicorandil group (n=105), trimetazidine group (n=104), nicorandil plus trimetazidine group (n=104). The control group received hydration and aspirin, β-blockers, statins and other conventional drugs for coronary heart disease. The remaining three groups were given respective medication on top of the medications used in control group at 48 hours prior to PCI. The levels of respective blood index were measured and compared among four groups at preoperative and at 72 hours post operation. The primary endpoint was the incidence of CIN. Results: The incidence of contrast-induced nephropathy (CIN) in the control group, nicorandil group, trimetazidine group, nicorandil plus trimetazidine group were 8.2%, 2.8%, 3.8%, 1.0% respectively, which was significantly lower in nicorandil plus trimetazidine group than in the control group (P=0.009). Multivariate logistic regression analysis showed that, compared with control group, the use of nicorandil plus trimetazidine strategy was related to decreased CIN incidence (OR=0.114, 95%CI: 0.015-0.880, P=0.037). Conclusions: In patients with acute coronary syndrome undergoing elective PCI, the use of nicorandil plus trimetazidine strategy is related to decreased CIN incidence.
ABSTRACT
Objective To study the genotype distribution and its association with acute coronary syndrome (ACS) of polymorphism of osteoprotegerin (OPG) gene promoter rs2073617T/C(950T/C) and the first exon rs2073618G/C(1181G/C) in Fujian Han population. Methods A total of seven hundred and twenty consecutive patients of unrelated Fujian Han people with ACS were enrolled in the present study. They were divided into ACS group and control group, 360 each. OPG gene 950T/C and 1181G/C were genotyped in all the patients using polymerase chain reaction restriction fragment length polymorphism (PCRRFLP). DNA sequences of enzyme digestion products were also analyzed. Results In Fujian Han population, the frequency of TC, TT, CC types of OPG 950T/C polymorphism in ACS patients and controls were 47.8%, 26.7% and 25.5% vs 43.3%, 33.3% and 23.3%; The frequency of GG, GC, CC types of OPG 1181G/C polymorphism in ACS patients and controls were 51.1%, 40.0% and 8.9% vs 60.0%, 35.0% and 5.0%. No significant differences were observed in the genotype and allelic frequency of OPG gene 950T/C and 1181G/C between the ACS and control groups. OPG gene 950T/C and 1181G/C showed no statistically significant difference between ACS patients with single-vessel, double-vessel and three or more-vessel disease. Conclusion OPG gene polymorphism of 950T/C and 1181G/C are not associated with ACS in Han population of Fujian.
ABSTRACT
Objective To study the genotype distribution and its association with acute coronary syndrome (ACS) of polymorphism of osteoprotegerin (OPG) gene promoter rs2073617T/C(950T/C) and the first exon rs2073618G/C(1181G/C) in Fujian Han population. Methods A total of seven hundred and twenty consecutive patients of unrelated Fujian Han people with ACS were enrolled in the present study. They were divided into ACS group and control group, 360 each. OPG gene 950T/C and 1181G/C were genotyped in all the patients using polymerase chain reaction restriction fragment length polymorphism (PCRRFLP). DNA sequences of enzyme digestion products were also analyzed. Results In Fujian Han population, the frequency of TC, TT, CC types of OPG 950T/C polymorphism in ACS patients and controls were 47.8%, 26.7% and 25.5% vs 43.3%, 33.3% and 23.3%; The frequency of GG, GC, CC types of OPG 1181G/C polymorphism in ACS patients and controls were 51.1%, 40.0% and 8.9% vs 60.0%, 35.0% and 5.0%. No significant differences were observed in the genotype and allelic frequency of OPG gene 950T/C and 1181G/C between the ACS and control groups. OPG gene 950T/C and 1181G/C showed no statistically significant difference between ACS patients with single-vessel, double-vessel and three or more-vessel disease. Conclusion OPG gene polymorphism of 950T/C and 1181G/C are not associated with ACS in Han population of Fujian.